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Macular Holes: Pathophysiology, Classification, and Treatment
a Chi
The development of a macular hole can be distressing for patients, often leading to central visual distortion and reduced vision. Jessica Chi explores the underlying pathophysiology of macular holes, and current classification systems used to stage macular holes; essential for guiding management and prognosis.
Approximately 90% of are idiopathic. They occur in approximately twice as many women compared to men, with peak incidence in women aged 70–79. An Australian study from Tasmania reported an incidence of full thickness macular holes (FTMH) as four per 100,000.
macular holes
Non-idiopathic causes of macular holes are rare under 40 years of age, with causes including trauma, high myopia, post- intraocular surgery, epiretinal membrane, hypertensive, or diabetic retinopathy.
Bilateral cases occur in between 7–12% of patients, with no clear systemic association reported.
PATHOPHYSIOLOGY With ageing, the vitreous undergoes liquefaction (synchysis) and progressive weakening of the vitreoretinal junction, eventually leading to posterior vitreous detachment (PVD). However, in abnormal PVD, liquefaction occurs but the vitreoretinal adhesion persists.
Persistent adhesion at the macula results in vitreomacular traction (VMT), which deforms the foveal architecture. Continued traction can lead to intraretinal splitting and progressive dehiscence of the retinal layers, which may ultimately result in the formation of a FTMH.
Gass Classification The original classification of macular holes was described by Gass.
Stage 1. Partial-thickness foveal detachment caused by VMT forming an intrafoveal pseudocyst, which may appear as a central yellow spot on fundus examination. Approximately half resolve spontaneously.
Stage 2. Small (<400 microns) FTMH with persistent VMT.
Stage 3. Large (>400 microns) FTMH with VMT present.
Stage 4. FTMH with complete posterior vitreous detachment (PVD).
A full-thickness macular hole is defined by a defect extending through all layers of the neurosensory retina, from the internal limiting membrane (ILM) to the retinal
A defect affecting
“Continued traction can lead to intraretinal splitting and progressive dehiscence of the retinal layers”
Figure 1. Fundus examination showing macular hole in the right eye with VMT.
Figure 2. Fundus examination showing macular hole in the left eye with VMT.
Consequently, many patients who undergo PVL or ocriplasmin injections will still require PPV, making the latter the gold standard treatment.
CASE STUDY Alice Leigh,* a 75-year-old female, presented with blurred vision in both eyes over the past
“Small holes are likely to spontaneously resolve and have the most favourable response to victrectomy...”
few weeks. She reported distorted vision, with lines appearing wavy (metamorphopsia) and did not feel confident driving. She denied any history of ocular trauma or surgery.
Her medical history was significant only for well-controlled hypertension.
Vision unaided was R 6/38, L 6/24=.
Refraction was R -0.75/-0.50x10 (6/24=), L -1.00/-1.50x153 (6/7.5), near add +2.50DS. No improvement was achieved with pinhole.
Anterior eye examination revealed grade 1 nuclear sclerosis bilaterally, but was otherwise unremarkable.
Fundus examination showed round, well- demarcated foveal defects in both eyes, suspicious for bilateral macula holes (Figures 1 and 2).
OCT demonstrated bilateral VMT. The right eye exhibited an oblique stage 2 FTMH
(Figure 3) while the left demonstrated a stage 1 macular hole (Figure 4).
Ms Leigh was referred to a vitreoretinal surgeon. PPV and ILM peel with gas tamponade were planned for the right eye. Given the lesser anatomical and functional impact in the left eye, the plan for the left eye was observation.
Two months following PPV surgery, Ms Leigh returned. She reported her vision had gradually improved. She was no longer aware of any distortions in her vision and she had resumed driving.
Vision unaided was R 6/15, L 6/15.
Refraction was -0.75/-0.50x40 (6/9), L -1.00/-1.50x153 (6/6-).
OCT revealed closure of her right FTMH, with residual foveal subretinal fluid (Figure 5). Fortunately, her left eye demonstrated spontaneous improvement without treatment (Figure 6).
However, the cataract in the right eye had progressed.
Jessica Chi is the Director of Eyetech Optometrists, an independent speciality contact lens practice in Melbourne. She is the current Victorian, and a past National President of the Cornea and Contact Lens Society. She is a clinical supervisor at the University of Melbourne, a member of Optometry Victoria Optometric Sector Advisory Group, and a Fellow of the Australian College of Optometry, the British Contact Lens Association, and the International Academy of Orthokeratology and Myopia Control.